Figure 4.

Structure-based substrate-binding pocket conservation analysis of M^pros from four different genera. Surface representation showing the conserved substrate-binding pockets from the ten CoV M^pros listed in Figure 2B. The background is PDCoV M^pro. Red: identical residues among all ten CoV M^pros; orange: substituted in two CoV M^pros. The S1, S2, S4, and S1′ pockets and the residues that form the substrate-binding pocket are labeled. N3 is shown in green.