Table 3.
The Km and kcat values of the representative Mpros from different CoVs.
| Genus | Coronaviruses |
Km (µM) |
kcat (s−1) |
References |
|---|---|---|---|---|
| Deltacoronavirus | PDCoV | 56.6 ± 1.9 | 0.030 ± 0.009 | In this study |
| Alphacoronavirus | HCoV-NL63 | 50.8± 3.4 | 0.098 ± 0.004 | [26] |
| HCoV-229E | 29.8 ± 0.9 | 1.27 ± 0.09 | [15] | |
| FIPV | 13.5 ± 1.8 | 0.6 ± 0.06 | [15] | |
| TGEV | 61 ± 5 | 1.39 ± 0.09 | [15] | |
| Betacoronavirus | SARS-CoV | 129 ± 7 | 0.14 ± 0.01 | [15] |
| HCoV-HKU1 | 83.2 ± 13.3 | 1.1 ± 0.12 | [29] | |
| MHV-A59 | 77 ± 5 | 0.083 ± 0.006 | [15] | |
| Gammacoronavirus | IBV | 139 ± 15 | 0.22 ± 0.03 | [15] |
Porcine deltacoronavirus, PDCoV; Human coronavirus NL63, HCoV-NL63; Human coronavirus 229E, HCoV-229E; Feline infectious peritonitis virus, FIPV; Transmissible gastroenteritis virus, TGEV; Severe acute respiratory syndrome coronavirus, SARS-CoV; Human coronavirus HKU1, HCoV-HKU1; Mouse hepatitis virus A59, MHV-A59; Infectious bronchitis virus, IBV.