Table 4.
Evaluation of the inhibitory activity of compounds targeting PDCoV Mpro. The inhibition ratio (Ir) is defined as the percent inactivation of the initial enzymatic activity of PDCoV Mpro.
| Compound | Inhibition Ratio (Ir) | Inhibitory Activity a |
|---|---|---|
| N3 | 62% | + + + |
| M1 c | 37% | + + |
| M2 c | 53% | + + + |
| M3 c | 21% | + |
| M5 c | - | N/A b |
| M6 c | - | N/A |
| M7 c | 30% | + + |
| M8 c | 20% | + |
| M10 c | 62% | + + + |
| M11 c | 23% | + |
| M12 c | 27% | + |
| M13 c | 21% | + |
| M14 c | 82% | + + + + + |
| M17 c | 39% | + + |
| M18 c | 50% | + + + |
| M19 c | 53% | + + + |
| M25 c | 74% | + + + + |
a Percentage inhibitory activity: + + + + +, >80%; + + + +, 70%−80%; + + +, 50%−70%; + +, 30%−50%; +, <30%. b No inhibition was observed. c The detailed structures and chemical synthesis of the compounds were described in reference [27].