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(A) Minimized average structure of SIRT1 in complex with p53-AMC peptide (green) and three molecules of resveratrol (gold). (B) Minimized average structure of SIRT1 in complex with p53-AMC peptide and two molecules of 10 (orange). In both panels, ligand–protein and ligand–peptide H-bonds are highlighted as black dashed lines. For clarity, the side chains of R1, H2 and K3 of the p53-AMC peptide are not shown.
