Scheme 1.
Synthesis of fascaplysin derivatives 3 and 4. Reagents and conditions: (a) I2 (0.8 equiv.), DMSO, 110 °C, 1 h, then tryptamine (1.0 equiv.), DMSO, 110 °C, 4 h; (b) 220 °C, 15 min, then HCl (aq).
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