Table 2.

The direct iodination of fascaplysin under various reaction conditions.

Experiment.	Heating (°C) or MW	Time, min	Reactant Ratio			Reaction Results
			1, mmol	I2, equiv.	DMSO, mL
1	120	280	0.011	18.8	1	mixture of 1 and 7
2	120	240	0.007	28	0.5	mixture of 1 and 7
3	120	120	0.007	28	1	decomposition of the mixture
4	MW, 50 W	18	0.04	5.3	1	mixture of 1 and 7 (50/50)
5	MW, 50 W	28	0.04	5.3	1	15 min—7 found, 28 min—decomposition of the mixture
6	MW, 45 W	30	0.04	5.3	1 (autoclave)	mixture of 1 and 7 (minor)
7	MW, 45 W	30	0.04	5.3	2	no reaction
8	MW, 45 W	30	0.01	18.8	1	mixture of 1 and 7 (minor)