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Permeation study of different treatment groups (pure diclofenac (DC), optimized diclofenac bilosomes (DC-BMs-opt), and diclofenac liposomes (DC-LP)). Study was performed in triplicate and result shown as mean ± SD. Statistical analysis performed between each group and p < 0.05 considered significant. *** highly significant to pure DC; ### significant to DC-LP; ** significant to pure DC.
