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Anti-inflammatory activity of different treatment groups (pure diclofenac (DC), optimized diclofenac bilosomes (DC-BMs-opt), and diclofenac liposomes (DC-LP)) compared with disease control. Study performed with six rats (n = 6) in each group and result shown as mean ± SD. Statistical analysis performed between each group and p < 0.05 considered significant. *** highly significant to diabetic control; ### significant to pure DC and DC- LP; ns, non-significant to pure DC and DC-LP.
