Table 1.
Formulation composition and their effect on vesicle size and entrapment efficiency.
| Code | Formulation Factor | Responses | ||||
|---|---|---|---|---|---|---|
| CHO (A; %) |
Lipid (B; %) |
Surfactant (C; %) |
Bile Salt (D; %) |
Vesicle Size (nm; R1) |
Entrapment Efficiency (%; R2) | |
| 1 | 0.1 | 0.5 | 0.5 | 1 | 169.34 | 50.23 |
| 2 | 0.5 | 0.5 | 0.5 | 1 | 284.53 | 88.23 |
| 3 | 0.1 | 1.5 | 0.5 | 1 | 275.34 | 75.43 |
| 4 | 0.5 | 1.5 | 0.5 | 1 | 380.14 | 92.32 |
| 5 | 0.3 | 1 | 0.3 | 0.5 | 328.12 | 65.02 |
| 6 | 0.3 | 1 | 0.7 | 0.5 | 260.34 | 84.12 |
| 7 | 0.3 | 1 | 0.3 | 1.5 | 291.65 | 76.32 |
| 8 | 0.3 | 1 | 0.7 | 1.5 | 218.54 | 81.32 |
| 9 | 0.1 | 1 | 0.5 | 0.5 | 243.45 | 58.43 |
| 10 | 0.5 | 1 | 0.5 | 0.5 | 335.27 | 85.12 |
| 11 | 0.1 | 1 | 0.5 | 1.5 | 203.16 | 72.02 |
| 12 | 0.5 | 1 | 0.5 | 1.5 | 297.65 | 94.03 |
| 13 | 0.3 | 0.5 | 0.3 | 1 | 248.24 | 57.23 |
| 14 | 0.3 | 1.5 | 0.3 | 1 | 357.00 | 75.12 |
| 15 | 0.3 | 0.5 | 0.7 | 1 | 200.43 | 77.32 |
| 16 | 0.3 | 1.5 | 0.7 | 1 | 298.14 | 93.11 |
| 17 | 0.1 | 1 | 0.3 | 1 | 256.76 | 60.23 |
| 18 | 0.5 | 1 | 0.3 | 1 | 345.65 | 81.87 |
| 19 | 0.1 | 1 | 0.7 | 1 | 194.54 | 70.21 |
| 20 | 0.5 | 1 | 0.7 | 1 | 290.00 | 90.24 |
| 21 | 0.3 | 0.5 | 0.5 | 0.5 | 242.87 | 57.25 |
| 22 | 0.5 | 1 | 0.7 | 1 | 341.54 | 83.51 |
| 23 | 0.3 | 0.5 | 0.5 | 1.5 | 210.00 | 77.87 |
| 24 | 0.3 | 1.5 | 0.5 | 1.5 | 306.23 | 85.23 |
| 25 | 0.3 | 1 | 0.5 | 1 | 270.21 | 79.01 |
| 26 | 0.3 | 1 | 0.5 | 1 | 270.43 | 79.09 |
| 27 | 0.3 | 1 | 0.5 | 1 | 269.36 | 80.87 |