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. 2022 Mar 8;12(3):421. doi: 10.3390/jpm12030421

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Program workflow for the comprehensive clinical decision support system (CDSS; GeneDose LIVE™, Coriell Life Sciences, Philadelphia, PA, USA) including pharmacogenomics-enriched comprehensive medication management (PGx + CMM). The CDSS enabled a wide variety of essential activities supporting the Quadruple Aim including member engagement and education, comprehensive pharmacogenetic testing, and pharmacist review. Moreover, the CDSS facilitated both the unification of PGx with CMM and the development of pharmacist-authored medication action plans (MAPs) that were observed to drive positive changes in economics and healthcare resource utilization. Abbreviations: PGx, pharmacogenomics; CMM, comprehensive medication management.