Study population definitions and inclusion/exclusion criteria. Invitations for the PGx + CMM program were sent to all active TRS members. Following minimal exclusions (age, continuous medical insurance coverage, and MAP availability), data from a total of 27,000 members were used in economic and clinical evaluations of program impact. Of these, 5288 individuals voluntarily participated in the program and were defined as the intervention group. Data from the remaining 22,357 individuals were used as a contemporaneous comparison (i.e., “control”) group in analyses of economic impact. The clinical evaluation included 4716 members of the intervention group who consented to be included in this research.