Yearly average charges to plan per patient per month (PMPM) for the identified intervention and control groups. In the 12 calendar months pre-program (2017), the intervention group (n = 5288) was associated with average medical insurance charges of $233.17 PMPM more than the control group (n = 22,357). During the first 32 months of the PGx + CMM program, the cost curve for the intervention group appears to flatten. In this same 32 month period, the intervention group showed a significant decrease of $218.34 PMPM compared to the control group, whose costs continued to increase linearly.