TABLE 3.
TK gene sequence modificationsa of VZV strains
| Virus | Nucleotide position (change) | Amino acid position (change) |
|---|---|---|
| ACV-sensitive strains | ||
| Ellen | ||
| Oka | ||
| D9507 | 536 (AGT→AAT) | 179 (Ser→Asn) |
| ACV-resistant strains | ||
| WMad | 497 (addition C) | 167 (frameshift→206 stop codon) |
| WStr | 143 (GAG→GGG) | 48 (Glu→Gly) |
| LYON6625 | 514 (GTT→CTT) | 172 (Val→Cys) |
| 536 (AGT→ATT) | 179 (Ser→Ile) | |
| 641–642 (deletion T-A) | 215 (frameshift→217 stop codon) | |
| SW689 | 428 (AGA→GGA) | 143 (Arg→Gly) |
a
Compared to the sequence of the ACV-sensitive reference strain Dumas (5). All strains have an amino acid change at position 288 (Ser→Leu) due to a nucleotide change at position 863 (C→T).