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. 2022 Mar 8;23(6):2914. doi: 10.3390/ijms23062914

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Proposed mechanism of action of Luteolin-7-O-glucoside (Lut7). Regarding the mitochondria, Lut7 prevented membrane depolarization induced by 6-OHDA and indirectly reduced mitochondrial dysfunction and oxidative stress. Lut7 also decreased Caspase-3 activity protecting cells against 6-OHDA-induced apoptosis. Additionally, at low concentrations, Lut7 was able to inhibit AChE activity, which may contribute to alleviating AD symptoms. In RAW264.7 cells, Lut7 was able to reduce TNF-α production (after 3 h), and induce IL-10 release (after 24 h), which may contribute to modulate the neuroinflammation.