Skip to main content
. 2022 Mar 2;12(3):362. doi: 10.3390/life12030362

Table 1.

The substrates of SET7/9-dependent methylation playing roles in proliferation and cellular stress response.

SET7/9 Target Protein Methylation Sites Effect of the Modification Reference
Histone H1 K12, K14, K17, K20,
K21, K27, K111
Modulation of the affinity of histone H1 to chromatin during human pluripotent cells differentiation [31]
Histone H1.4 K34, K127, K129, K130 Prevention of acetylation at the same sites, heterochromatin formation [31]
Histone H2.A K5, K13, K15 Unknown [3]
Histone H2.B K15 Unknown [3]
Histone H3 K4 Activation of transcription [1]
Suv39H1 K25, K123 Heterohromatin relaxation, genome instability [32]
DNMT1 K142 Promotion of DNMT1 ubiquitination and proteasomal degradation [33]
K1094 Decrease of the DNMT1 level [34]
TAF7 K5 Enhancement of TAF7 activity as co-factor of RNA polymerase II [8]
TAF10 K189 Enhancement of TAF10 activity as co-factor of RNA polymerase II, activation of transcription of TAF10 target genes [35]
YAP1 K494 Retention of YAP1 in the cytoplasm [17]
β-catenin K180 Promotion of β-catenin ubiquitination by (GSK)-3b and its subsequent proteasomal degradation [36]
STAT3 K140 Dissociation of STAT3 from promoter elements, downregulation of STAT3-dependent genes expression [37]
E2F1 K185 Promotion of E2F1 ubiquitination and subsequent proteasomal degradation [38]
Unknown Enhancement of E2F transactivation of its target genes [39]
pRb K873 Enhancement of pRB-dependent repression of transcription [40]
K810 Promotion of p65/RelA ubiquitination and its subsequent proteasomal degradation [41]
YY1 K173, K411 Retention of YY1 in the cytoplasm [42]
p65/RelA K37 Translocation to the nucleus and transactivation of target genes [43]
K314, K315 Promotion of p65/RelA ubiquitination and subsequent proteasomal degradation [44]
FOXO3 K270 Downregulation of FOXO3-dependent transactivation of BIM [45]
K271 Increase of the FOXO3 transactivation potential [46]
Hif1α K32 Suppression of Hif1α transactivation of its target genes [47,48]
p53 K372 Stabilization, translocation to the nucleus and transactivation of target genes [7]
SIRT1 K233, K235, K236, K238 Enhancement of SIRT1-dependent p53 acetylation and activation [49]