Table 1.

The substrates of SET7/9-dependent methylation playing roles in proliferation and cellular stress response.

SET7/9 Target Protein	Methylation Sites	Effect of the Modification	Reference
Histone H1	K12, K14, K17, K20, K21, K27, K111	Modulation of the affinity of histone H1 to chromatin during human pluripotent cells differentiation	[31]
Histone H1.4	K34, K127, K129, K130	Prevention of acetylation at the same sites, heterochromatin formation	[31]
Histone H2.A	K5, K13, K15	Unknown	[3]
Histone H2.B	K15	Unknown	[3]
Histone H3	K4	Activation of transcription	[1]
Suv39H1	K25, K123	Heterohromatin relaxation, genome instability	[32]
DNMT1	K142	Promotion of DNMT1 ubiquitination and proteasomal degradation	[33]
	K1094	Decrease of the DNMT1 level	[34]
TAF7	K5	Enhancement of TAF7 activity as co-factor of RNA polymerase II	[8]
TAF10	K189	Enhancement of TAF10 activity as co-factor of RNA polymerase II, activation of transcription of TAF10 target genes	[35]
YAP1	K494	Retention of YAP1 in the cytoplasm	[17]
β-catenin	K180	Promotion of β-catenin ubiquitination by (GSK)-3b and its subsequent proteasomal degradation	[36]
STAT3	K140	Dissociation of STAT3 from promoter elements, downregulation of STAT3-dependent genes expression	[37]
E2F1	K185	Promotion of E2F1 ubiquitination and subsequent proteasomal degradation	[38]
	Unknown	Enhancement of E2F transactivation of its target genes	[39]
pRb	K873	Enhancement of pRB-dependent repression of transcription	[40]
	K810	Promotion of p65/RelA ubiquitination and its subsequent proteasomal degradation	[41]
YY1	K173, K411	Retention of YY1 in the cytoplasm	[42]
p65/RelA	K37	Translocation to the nucleus and transactivation of target genes	[43]
	K314, K315	Promotion of p65/RelA ubiquitination and subsequent proteasomal degradation	[44]
FOXO3	K270	Downregulation of FOXO3-dependent transactivation of BIM	[45]
	K271	Increase of the FOXO3 transactivation potential	[46]
Hif1α	K32	Suppression of Hif1α transactivation of its target genes	[47,48]
p53	K372	Stabilization, translocation to the nucleus and transactivation of target genes	[7]
SIRT1	K233, K235, K236, K238	Enhancement of SIRT1-dependent p53 acetylation and activation	[49]