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. 2022 Mar 19;14(3):676. doi: 10.3390/pharmaceutics14030676

Scheme 1.

Scheme 1

Schematic illustration of the molecular tuning of IR-786 for enhanced photothermal cancer therapy. The integration of a chloro-cyclohexene ring and side carboxyl groups on the heptamethine skeleton is the key to improving tumor targetability based on a structure-inherent targeting strategy.