Figure 2.

Secondary domains involved in nonribosomal peptide synthesis: structural organization of linear gramicidin, anabaenopeptilides, syringafactin, serobactin, vancomycin, maremycin, indigoidine, previoprolide, and thiocoraline synthetases containing secondary domains with monomer modification enzymatic activity. Canonical domains are depicted in grey, while secondary domains are highlighted with color. A, adenylation domain; C (^LC_L, ^DC_L, or C_start), condensation domain; C/E, dual condensation and epimerization domain; T, thiolation domain; F, formylation domain; E, epimerization domain, R, reductase domain; MT, methyltransferase domain, H, halogenase domain; TauD, aspartate hydroxylation domain; X, X domain; Ox, oxidation domain; FkbH, FkbH domain; Cy, cyclization domain; UN, domain with unknown function; AL, Acyl-CoA ligase. The white squared domain is related to PKSs.