Figure 3.

EGCG-induced SIRT-1 modulation of lipid metabolism, antioxidant pathways, inhibition of fatty acid synthesis, and inflammatory response pathways. ATGL increases lipolysis of fats, while increased CAT boosts the antioxidant status. NF-kB regulates several pro-inflammatory pathways, including the production of inflammatory cytokines such as IL-6 and TNFα. Abbreviations: ATGL: adipose triglyceride lipase; CAT: catalase; FOXO-1: fork-head box O1; IL: interleukin; NF-κB: nuclear factor-κB; PGC: peroxisome proliferator-activated receptor-gamma coactivator; PPAR: peroxisome proliferator receptor; SREBP: sterol regulatory element binding protein; TNF: tumor necrosis factor.