Table 1.
Differentially expressed genes of MAC-FOXO382 in FOXO3-deficient mouse macrophages relative to control (n = 3, FC ≥|1.5|, p < 0.001).
| Gene | Gene Name | FC | p-Value | |
|---|---|---|---|---|
| 1 | Stfa1 | Stefin-A 1 | 225.6 | 4.8 × 10−8 |
| 2 | Entpd3 | Ectonucleoside Triphosphate Diphosphohydrolase 3 | 113.6 | 3.0 × 10−9 |
| 3 | Amer2 | APC Membrane Recruitment Protein 2 | 67.7 | 7.6 × 10−10 |
| 4 | S100a9 | S100 Calcium Binding Protein A9 | 66.7 | 1.1 × 10−4 |
| 5 | Mrgpra2b | MAS Related GPR Family Member X2 | 35.3 | 2.4 × 10−4 |
| 6 | Asprv1 | Aspartic Peptidase Retroviral-like 1 | 33.9 | 7.5 × 10−18 |
| 7 | Sycp2 | Synaptonemal Complex Protein 2 | 30.2 | 1.6 × 10−13 |
| 8 | Chil1 | Chitinase 3-like 1 | 29.5 | 1.4 × 10−6 |
| 9 | Olfm4 | Olfactomedin 4 | 24.3 | 6.2 × 10−8 |
| 10 | Cxcr2 | C-X-C Motif Chemokine Receptor 2 | 21.5 | 8.4 × 10−35 |
| 11 | Catspere2 | Catsper Channel Auxiliary Subunit Epsilon | 18.6 | 9.7 × 10−5 |
| 12 | Il1f9 | Interleukin 1 Family, Member 9 | 13.6 | 5.9 × 10−13 |
| 13 | Amd2 | Adenosylmethionine Decarboxylase 1 Pseudogene 2 | 11.8 | 2.6 × 10−34 |
| 14 | Alas2 | 5′-Aminolevulinate Synthase 2 | 10.1 | 1.9 × 10−5 |
| 15 | S100a8 | S100 Calcium-binding Protein A8 | 9.9 | 4.9 × 10−7 |
| 16 | Steap4 | Six-Transmembrane Epithelial Antigen Of Prostate 4 | 8.0 | 2.1 × 10−12 |
| 17 | Il1r2 | Interleukin 1 Receptor Type 2 | 7.9 | 6.6 × 10−8 |
| 18 | Hba-a2 | Hemoglobin Subunit Alpha 2 | 7.7 | 3.1 × 10−6 |
| 19 | Slc38a4 | Solute Carrier Family 38 Member 4 | 7.7 | 3.9 × 10−8 |
| 20 | Stra6 | Stimulated By Retinoic Acid 6 | 7.2 | 3.7 × 10−5 |
| 21 | Col24a1 | Collagen Type XXIV Alpha 1 Chain | 6.7 | 9.3 × 10−6 |
| 22 | Hba-a1 | Hemoglobin Subunit Alpha 1 | 5.9 | 1.7 × 10−7 |
| 23 | Trem1 | Triggering Receptor Expressed On Myeloid Cells 1 | 5.7 | 1.2 × 10−15 |
| 24 | Lin28a | Lin-28 Homolog A | 5.6 | 1.5 × 10−4 |
| 25 | Il1b | Interleukin 1 Beta | 5.4 | 1.5 × 10−9 |
| 26 | Ambp | Alpha-1-Microglobulin/Bikunin Precursor | 5.1 | 2.3 × 10−4 |
| 27 | Ifitm1 | Interferon-induced Transmembrane Protein 1 | 5.1 | 5.8 × 10−5 |
| 28 | Nfe2l3 | Nuclear Factor, Erythroid 2-like 3 | 4.9 | 1.9 × 10−5 |
| 29 | Kirrel | Kin Of Irregular Chiasm-like Protein 1 | 4.9 | 9.2 × 10−5 |
| 30 | Lamb1 | Laminin Subunit Beta 1 | 4.3 | 6.0 × 10−7 |
| 31 | Serpinh1 | Serpin Peptidase Inhibitor, Clade H, Member 1, | 4.0 | 1.7 × 10−6 |
| 32 | Adamts1 | ADAM Metallopeptidase With Thrombospondin Type 1 Motif 1 | 3.9 | 1.8 × 10−4 |
| 33 | Pkhd1l1 | Polycystic Kidney and Hepatic Disease 1-like 1 | 3.8 | 1.8 × 10−4 |
| 34 | Fads2 | Fatty Acid Desaturase 2 | 3.7 | 6.2 × 10−6 |
| 35 | Col1a1 | Collagen Type I Alpha 1 Chain | 3.6 | 2.5 × 10−4 |
| 36 | Dmkn | Dermokine | 3.6 | 4.0 × 10−5 |
| 37 | Rbp1 | Retinol-binding Protein 1 | 3.5 | 7.2 × 10−5 |
| 38 | Tcaf1 | TRPM8 Channel Associated Factor 1 | 3.4 | 9.0 × 10−8 |
| 39 | Hpgd | 15-Hydroxyprostaglandin Dehydrogenase | 3.4 | 2.1 × 10−7 |
| 40 | septin3 | Neuronal-specific Septin-3 | 3.4 | 6.2 × 10−5 |
| 41 | Nr4a3 | Nuclear Receptor Subfamily 4 Group A Member 3 | 3.3 | 5.8 × 10−7 |
| 42 | Ccl2 | C-C Motif Chemokine Ligand 2 | 3.3 | 3.1 × 10−5 |
| 43 | Ltbp2 | Latent Transforming Growth Factor Beta-binding Protein 2 | 3.3 | 1.6 × 10−4 |
| 44 | Dclk1 | Doublecortin-like Kinase 1 | 3.2 | 3.6 × 10−6 |
| 45 | Map1b | Microtubule Associated Protein 1B | 3.2 | 2.2 × 10−4 |
| 46 | Wt1 | Wilms Tumor 1 | 3.2 | 4.1 × 10−5 |
| 47 | Col1a2 | Collagen Type I Alpha 2 Chain | 3.1 | 1.9 × 10−4 |
| 48 | Ptprf | Protein Tyrosine Phosphatase Receptor Type F | 3.0 | 2.2 × 10−4 |
| 49 | Krt19 | Keratin 19 | 2.9 | 1.0 × 10−4 |
| 50 | Arhgef17 | Rho-specific Guanine-Nucleotide Exchange Factor | 2.8 | 1.5 × 10−4 |
| 51 | Il1r1 | Interleukin 1 Receptor Type 1 | 2.7 | 6.3 × 10−5 |
| 52 | Treml4 | Triggering Receptor Expressed On Myeloid Cells-like 4 | 2.7 | 1.9 × 10−4 |
| 53 | Vcan | Versican | 2.5 | 1.3 × 10−5 |
| 54 | Klrb1b | Killer Cell Lectin-like Receptor B1 | 2.4 | 2.9 × 10−5 |
| 55 | Olr1 | Oxidized Low Density Lipoprotein Receptor 1 | 2.1 | 2.8 × 10−4 |
| 56 | Pram1 | PML-RARA Regulated Adaptor Molecule 1 | 2.1 | 2.2 × 10−5 |
| 57 | Ccnb1 | Cyclin B1 | 2.1 | 1.9 × 10−4 |
| 58 | Npl | N-Acetylneuraminate Pyruvate Lyase | 2.0 | 6.2 × 10−5 |
| 59 | Cdk1 | Cyclin-dependent Kinase 1 | 1.9 | 1.5 × 10−4 |
| 60 | Tbc1d16 | TBC1 Domain Family Member 16 | 1.8 | 7.4 × 10−5 |
| 61 | Dab2 | DAB Adaptor Protein 2 | 1.8 | 3.1 × 10−7 |
| 62 | Nfil3 | Nuclear Factor, Interleukin 3 Regulated | 1.8 | 2.9 × 10−5 |
| 63 | Tbc1d4 | TBC1 Domain Family Member 4 | 1.7 | 1.2 × 10−4 |
| 64 | Samsn1 | SAM Domain, SH3 Domain And Nuclear Localization Signals 1 | 1.5 | 2.6 × 10−5 |
| 65 | Kcnk13 | Potassium Two Pore Domain Channel Subfamily K Member 13 | 1.5 | 1.4 × 10−4 |
| 66 | Fmo5 | Flavin Containing Dimethylaniline Monoxygenase 5 | −1.6 | 1.2 × 10−4 |
| 67 | Ip6k1 | Inositol Hexakisphosphate Kinase 1 | −1.6 | 8.4 × 10−5 |
| 68 | Wdr45 | WD Repeat Domain 45 | −1.7 | 2.2 × 10−5 |
| 69 | Serinc5 | Serine Incorporator 5 | −1.7 | 3.2 × 10−5 |
| 70 | Mrgprx2 | MAS-Related GPR Family Member X2 | −1.9 | 3.7 × 10−1 |
| 71 | Maml2 | Mastermind-like Transcriptional Coactivator 2 | −1.9 | 7.2 × 10−5 |
| 72 | Vsig10 | V-Set And Immunoglobulin Domain-containing 10 | −2.2 | 4.5 × 10−5 |
| 73 | Dnajc28 | DnaJ Heat Shock Protein Family (Hsp40) Member C28 | −2.2 | 7.9 × 10−7 |
| 74 | Rab6b | RAB6B, Member RAS Oncogene Family | −2.5 | 2.5 × 10−5 |
| 75 | Ypel3 | Yippee Like 3 | −2.9 | 4.2 × 10−19 |
| 76 | Armc2 | Armadillo Repeat-containing 2 | −3.1 | 2.8 × 10−6 |
| 77 | Cdkn2a | Cyclin-dependent Kinase Inhibitor 2A | −5.5 | 8.4 × 10−6 |
| 78 | Slc15a2 | Solute Carrier Family 15 Member 2 | −6.6 | 1.0 × 10−4 |
| 79 | Clec2g | C-Type Lectin Domain Family 2 Member D | −8.9 | 2.1 × 10−20 |
| 80 | Camk2b | Calcium/Calmodulin-dependent Protein Kinase II Beta | −9.4 | 3.2 × 10−11 |
| 81 | Slc25a27 | Solute Carrier Family 25 Member 27 | −9.4 | 4.3 × 10−6 |
| 82 | Foxo3a | Forkhead Box O3 | −22.0 | 8.1 × 10−43 |