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. 2022 Feb 27;13(3):440. doi: 10.3390/genes13030440

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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LncRNA XR_001039544.4 knockdown inhibits the secretion of gonadotropins in pituitary cells. (A,B) mRNA expression of lncRNA XR_001039544.4 and LHB in sheep pituitary cells treated with siRNAs were decreased compared to the negative control (NC), as determined by qPCR. (C) LH secretion was detected by ELISA. (E) mRNA expression of PCNA in lncRNA XR_001039544.4-knockdown pituitary cells. (D,F) Pituitary-cell proliferation was detected using EDU. Scale bars, 100 μm. The data are shown as the mean ± SEM of at least three independent experiments. Statistical significance was analyzed by one-way ANOVA and Student t-test (** p < 0.01).