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. 2022 Mar 9;23(6):2944. doi: 10.3390/ijms23062944

Figure 1.

Figure 1

Supplementation of fibrinogen increases clot density. Clots contained 30% PNP or FDP, 16 µM phospholipids, ±FibCLOT®, RiaSTAP® or cryoprecipitate at 0.5–2 mg/mL. Clotting was initiated with 0.1 U/mL thrombin and 10.6 mM CaCl2 and with a change in absorbance measured at 405 nm. (A–C) Absorbance curves. (D) Correlation of maximal absorbance with the concentration of fibrinogen. (E–G) Slope of clot formation, indicative of the rate of fibrin formation. Data shown are mean ± SEM, n = 4, * p < 0.05, and *** p < 0.001.