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Clot strength is directly proportional to the concentration of fibrinogen supplementation. Thromboelastography was performed on whole blood (WB) or 40% hemodiluted clots (HD) ± (A) RiaSTAP®, (B) cryoprecipitate or (C) FibCLOT® (0.5–2 mg/mL) using EXTEM reagent and analyzed using ROTEM thromboelastography. Data represent mean data ± SEM of maximum clot firmness (MCF). (D) Correlation of MCF with fibrinogen concentration. n = 3, * p < 0.05, ** p < 0.01, *** p < 0.001 vs. 0.5 mg/mL.
