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Clots formed after hemodilution are stabilized by fibrinogen supplementation. Whole blood or 40% hemodiluted (HD) blood spiked with cryoprecipitate, RiaSTAP® or FibCLOT® (1 mg/mL), and tPA (2.5 nM) was run on a QStat® cartridge using a Quantra® Haemostasis Analyzer. (A) Clot strength, (B) fibrinogen contribution to clot strength and (C) clot stability against lysis. Data represent mean ± SEM * p < 0.05, ** p < 0.01, *** p < 0.001, vs. HD. n = 3.
