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. 2022 Mar 10;14(3):604. doi: 10.3390/pharmaceutics14030604

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The survival curves of wax moth larvae infected by S. aureus and treated by peptide Temporin-1CEh, T1CEh-KKPW, T1CEh-KKPWW and T1CEh-KKPWW2, as well as infected by E. coli and treated by peptide T1CEh-KKPWW2. For the treatment of S. aureus infection, the positive and negative controls were 50 mg/kg of vancomycin and 0.9% NaCl solution, respectively. For the treatment of E. coli infection, the positive and negative controls were 25 mg/kg of ampicillin and 0.9% NaCl solution, respectively. The statistical analyses were performed by using the Mantel–Cox test between the negative group and dose groups, as well as the significant difference was indicated as * (p < 0.05), *** (p < 0.001) and **** (p < 0.0001). The significant levels were indicated in parentheses behind the legend keys of each dose group.

The survival curves of wax moth larvae infected by S. aureus and treated by peptide Temporin-1CEh, T1CEh-KKPW, T1CEh-KKPWW and T1CEh-KKPWW2, as well as infected by E. coli and treated by peptide T1CEh-KKPWW2. For the treatment of S. aureus infection, the positive and negative controls were 50 mg/kg of vancomycin and 0.9% NaCl solution, respectively. For the treatment of E. coli infection, the positive and negative controls were 25 mg/kg of ampicillin and 0.9% NaCl solution, respectively. The statistical analyses were performed by using the Mantel–Cox test between the negative group and dose groups, as well as the significant difference was indicated as * (p < 0.05), *** (p < 0.001) and **** (p < 0.0001). The significant levels were indicated in parentheses behind the legend keys of each dose group.