Table 1.
Demographic, clinical, biological characteristics at baseline.
| TCZ+DEX (n = 224) | DEX (n = 226) | |
|---|---|---|
| Age (years) | 63·6 [52·6–73·3] | 63·2 [53·6–73·3] |
| Male, n/N (%) | 146/224 (65%) | 159/226 (70%) |
| Weight (kg) | 82·0 [70·0–93·5] | 81·5 [73·5–90·5] (n = 224) |
| BMI (kg/m²) | 27·4 [24·8–31·2] (n = 178) | 28·2 [24·7–31·9] (n = 191) |
| Obesity (BMI ≥30 kg/m²), n/N (%) | 62/220 (28%) | 63/224 (28%) |
| WHO score (0–10) | 5 [5–5] | 5 [5–5] |
| WHO score (0–10) = 5, n/N (%) | 224/224 (100%) | 226/226 (100%) |
| Temperature ( °C) | 37·1 [36·7–38·0] | 37·1 [36·7–38·0] |
| Respiratory rate (breaths / min) | 24·0 [21·0–30·0] (n = 203) | 25·0 [22·0–30·0] (n = 202) |
| Flow (L/min) | 5·0 [3·0–6·0] | 5·0 [3·0–6·0] |
| SpO2 (%) | 94·0 [92·0–96·0] | 94·0 [92·0–95·0] |
| Time from symptoms onset to randomization (days) | 9 [7–11] (n = 218) | 9 [7–11] (n = 222) |
| Co-existing conditions, n/N (%) | ||
| Hypertension | 80/221 (36%) | 84/221 (38%) |
| Chronic cardiac disease | 32/221 (14%) | 38/222 (17%) |
| Diabetes | 56/220 (25%) | 49/221 (22%) |
| Chronic kidney disease (stage 1 to 3) or dialysis | 20/221 (9%) | 12/221 (5%) |
| Asthma | 24/220 (11%) | 13/220 (6%) |
| Chronic pulmonary disease (not asthma) | 14/221 (6%) | 18/222 (8%) |
| Active malignant neoplasm | 8/221 (4%) | 11/222 (5%) |
| Smoking | ||
| No | 184/220 (84%) | 177/219 (80%) |
| Current | 18/220 (8%) | 10/219 (5%) |
| Former | 18/220 (8%) | 32/219 (15%) |
| Laboratory values | ||
| C-reactive protein (CRP) (mg/L) | 98 [58–147] (n = 215) | 94 [54–150] (n = 220) |
| D-Dimer (µg/L) | 807 [596–1344] (n = 204) | 922 [562–1347] (n = 201) |
| Lymphocyte count (G/L), | 0·7 [0·5–1·0] (n = 218) | 0·7 [0·6–1·1] (n = 220) |
| Ferritin (mg/L) | 988 [525–1746] (n = 147) | 1026 [484–1693] (n = 145) |
| LDH (IU/L) | 429 [335–537] (n = 169) | 398 [314–509] (n = 169) |
BMI denotes body mass index, LDH Lactate dehydrogenase. Values are median [interquartile range] unless stated.