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. 2022 Mar 25;79(4):206. doi: 10.1007/s00018-022-04224-2

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© The Author(s) 2022, corrected publication 2022

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Fig. 7 — Characterisation of neutrophils and neutrophil extracellular traps (NETs) in the cerebellum at P15 during chronic CCM. A–D Representative immunofluorescence for deposition of NETs in Ccm3^iECKO mice during chronic CCM, at P15. A Citrullinated histone H3 (green), Ly6g (red), DAPI (blue) and isolectin B4 (grey). B MPO (green), citrullinated histone H3 (red), DAPI (blue) and isolectin B4 (grey). C Citrullinated histone H3 (green), CD41 (red), DAPI (blue) and isolectin B4 (grey). D Proportions (%) of lesions with (left) or without (right) fibrinogen/fibrin signals that attract (black bar) or do not attract (grey bar) neutrophils. Total number of lesions analysed, 79 (in 4 mice). ****P < 0.0001, for cavernoma without and with fibrinogen/fibrin signals (Fisher’s exact tests). E Anti-Ly-6B.2 (green), fibrinogen/fibrin (red), DAPI (blue) and isolectin B4 (grey). White arrows: NETs (A–C); neutrophils (E). Scale bars: 50 μm (A–C); 200 μm (E)