Table 1.

Immune-related differentially expressed genes identified through RNA-Seq of endothelial cells isolated from Ccm3^iECKO mice during acute and chronic CCM, along with some of their functions

Gene	Function
Il-1b	Proinflammatory cytokine, promotes activation and acute phase response
Tnf	Proinflammatory cytokine, promotes activation and acute phase response
H2-Ab1	MHC class II, antigen presentation
Cxcl1/KC/GRO	Chemoattractant for neutrophils
Cxcl2/MIP2a	Chemoattractant for neutrophils. Expressed at inflammation sites and might suppress haematopoietic progenitor cell proliferation
Cx3cl1	Chemoattracts T cells and monocytes; promotes adhesion of leukocytes to activated endothelial cells
Ccl2/MCP-1	Shows chemotactic activity for monocytes and basophils
Ccl3/Mip1a	Involved in recruitment and activation of polymorphonuclear leukocytes
Vcam1	Mediates leukocyte-endothelial cell adhesion and signal transduction
Icam1	Upon activation, leukocytes bind to endothelial cells via ICAM-1/LFA-1 and transmigrate into tissues
P-selectin (Selp)	Mediates interaction of activated endothelial cells or platelets with leukocytes
E-selectin (Sele)	Mediates adhesion of neutrophils in activated endothelium through interaction with SELPLG/PSGL1