TABLE 3.
In vitro activity of AG7088 against picornavirus infectiona
| Virus strain | AG7088
|
Pirodavir
|
Pleconaril
|
|||
|---|---|---|---|---|---|---|
| EC50 (μM) | EC90 (μM) | EC50 (μM) | EC90 (μM) | EC50 (μM) | EC90 (μM) | |
| CAV 21 | 0.147 ± 0.024 | 0.314 ± 0.073 | 4.833 | >10 | 0.037 ± 0.048 | 0.148 ± 0.150 |
| CVB 3 | 0.183 ± 0.161 | 0.340 ± 0.321 | >10 | >10 | >10 | >10 |
| EV 11 | 0.014 ± 0.003 | 0.033 ± 0.015 | >10 | >10 | 0.165 | 0.275 |
| ETV 70 | 0.007 ± 0.006 | 0.066 ± 0.119 | 0.443 | 0.899 | 1.297, 0.726 | 2.726, 2.492 |
a
Antiviral efficacy was determined by measuring XTT dye reduction following 1 to 5 days of infection as described in Materials and Methods. Results represent the means ± standard deviations (three to six experiments) or individual values (one or two experiments).