Table 2.
HR (95% CIs) for vertebral fx in the PA groups with subgroup analyses according to age and gender.
| Characteristics | No. of Vertebral fx/ No. of Participants |
Follow-Up Duration, PY |
Incidence Rate, per 100 PY |
Hazard Ratios for Vertebral fx |
p for Interaction |
|||
|---|---|---|---|---|---|---|---|---|
| Crude 1 | p-Value | Adjusted 1,2 | p-Value | |||||
| Total participants (n = 175,860) | ||||||||
| Low PA | 12,787/58,620 (21.8) | 108,317 | 11.8 | 1 | 1 | |||
| Moderate PA | 6233/58,620 (10.6) | 129,073 | 4.8 | 0.43 (0.41–0.44) | <0.001 * | 0.43 (0.42–0.44) | <0.001 * | |
| High PA | 4042/58,620 (6.9) | 136,100 | 3.0 | 0.27 (0.26–0.28) | <0.001 * | 0.27 (0.26–0.28) | <0.001 * | |
| Age group | <0.001 * | |||||||
| Age < 65 years old (n = 38,367) | ||||||||
| Low PA | 1962/12,789 (15.3) | 26,400 | 7.4 | 1 | 1 | |||
| Moderate PA | 779/12,789 (6.1) | 30,351 | 2.6 | 0.35 (0.33–0.37) | <0.001 * | 0.36 (0.34–0.38) | <0.001 * | |
| High PA | 450/12,789 (3.5) | 31,412 | 1.4 | 0.19 (0.18–0.20) | <0.001 * | 0.20 (0.18–0.21) | <0.001 * | |
| Age ≥ 65 years old (n = 137,493) | ||||||||
| Low PA | 10,825/45,831 (23.6) | 81,917 | 13.2 | 1 | 1 | |||
| Moderate PA | 5454/45,831 (11.9) | 98,722 | 5.5 | 0.47 (0.45–0.48) | <0.001 * | 0.47 (0.45–0.49) | <0.001 * | |
| High PA | 3592/45,831 (7.8) | 104,688 | 3.4 | 0.31 (0.30–0.32) | <0.001 * | 0.31 (0.30–0.32) | <0.001 * | |
| Gender | 0.093 | |||||||
| Men (n = 21,138) | ||||||||
| Low PA | 1917/7046 (27.2) | 12,757 | 15.0 | 1 | 1 | |||
| Moderate PA | 1112/7046 (15.8) | 15,246 | 7.3 | 0.51 (0.47–0.55) | <0.001 * | 0.51 (0.47–0.55) | <0.001 * | |
| High PA | 754/7046 (10.7) | 16,382 | 4.6 | 0.33 (0.30–0.36) | <0.001 * | 0.33 (0.31–0.36) | <0.001 * | |
| Women (n = 154,722) | ||||||||
| Low PA | 10,870/51,574 (21.1) | 95,560 | 11.4 | 1 | 1 | |||
| Moderate PA | 5121/51,574 (9.9) | 113,827 | 4.5 | 0.41 (0.40–0.43) | <0.001 * | 0.42 (0.40–0.43) | <0.001 * | |
| High PA | 3288/51,574 (6.4) | 119,718 | 2.7 | 0.26 (0.25–0.27) | <0.001 * | 0.26 (0.25–0.27) | <0.001 * | |
CCI, Charlson comorbidity index; CIs, confidence intervals; DBP, diastolic blood pressure; fx, fracture; HR, hazard ratio; PA, physical activity; PY, person–year; SBP, systolic blood pressure. * Stratified Cox proportional hazard model, significance at <0.05 with Bonferroni correction (α = 0.05/3). 1 Stratified by gender, age, income within household unit, and region of residence. 2 Adjusted for total cholesterol, SBP, DBP, fasting blood glucose, obesity, smoking, alcohol consumption, and CCI score.