Table 3.
HR (95% CIs) for hip fx in the PA groups with subgroup analyses according to age and gender.
| Characteristics | No. of Hip fx/ No. of Participants |
Follow-up Duration, PY |
Incidence Rate, per 100 PY |
Hazard Ratios for Hip fx |
p for Interaction |
|||
|---|---|---|---|---|---|---|---|---|
| Crude 1 | p-Value | Adjusted 1,2 | p-Value | |||||
| Total participants (n = 175,860) | ||||||||
| Low PA | 2048/58,620 (3.5) | 139,819 | 1.5 | 1 | 1 | |||
| Moderate PA | 984/58,620 (1.7) | 142,750 | 0.7 | 0.47 (0.44–0.51) | <0.001 * | 0.51 (0.47–0.55) | <0.001 * | |
| High PA | 687/58,620 (1.2) | 143,707 | 0.5 | 0.33 (0.30–0.36) | <0.001 * | 0.37 (0.34–0.40) | <0.001 * | |
| Age group | <0.001 * | |||||||
| Age < 65 years old (n = 38,367) | ||||||||
| Low PA | 230/12,789 (1.8) | 31,829 | 0.7 | 1 | 1 | |||
| Moderate PA | 81/12,789 (0.6) | 32,213 | 0.3 | 0.33 (0.28–0.39) | <0.001 * | 0.35 (0.30–0.42) | <0.001 * | |
| High PA | 53/12,789 (0.4) | 32,338 | 0.2 | 0.20 (0.17–0.25) | <0.001 * | 0.23 (0.18–0.28) | <0.001 * | |
| Age ≥ 65 years old (n = 137,493) | ||||||||
| Low PA | 1818/45,831 (4.0) | 107,990 | 1.7 | 1 | 1 | |||
| Moderate PA | 903/45,831 (2.0) | 110,537 | 0.8 | 0.52 (0.47–0.56) | <0.001 * | 0.56 (0.51–0.61) | <0.001 * | |
| High PA | 634/45,831 (1.4) | 111,369 | 0.6 | 0.37 (0.34–0.41) | <0.001 * | 0.42 (0.38–0.46) | <0.001 * | |
| Gender | 0.009 * | |||||||
| Men (n = 21,138) | ||||||||
| Low PA | 554/7046 (7.9) | 16,666 | 3.3 | 1 | 1 | |||
| Moderate PA | 311/7046 (4.4) | 17,311 | 1.8 | 0.54 (0.47–0.63) | <0.001 * | 0.59 (0.51–0.68) | <0.001 * | |
| High PA | 199/7046 (2.8) | 17,630 | 1.1 | 0.35 (0.30–0.41) | <0.001 * | 0.40 (0.34–0.47) | <0.001 * | |
| Women (n = 154,722) | ||||||||
| Low PA | 1494/51,574 (2.9) | 123,153 | 1.2 | 1 | 1 | |||
| Moderate PA | 673/51,574 (1.3) | 125,439 | 0.5 | 0.44 (0.40–0.48) | <0.001 * | 0.48 (0.43–0.52) | <0.001 * | |
| High PA | 488/51,574 (1.0) | 126,077 | 0.4 | 0.32 (0.29–0.35) | <0.001 * | 0.35 (0.32–0.39) | <0.001 * | |
CCI, Charlson comorbidity index; CIs, confidence intervals; DBP, diastolic blood pressure; fx, fracture; HR, hazard ratio; PA, physical activity; PY, person–year; SBP, systolic blood pressure. * Stratified Cox proportional hazard model, significance at <0.05 with Bonferroni correction (α = 0.05/3). 1 Stratified by gender, age, income within household unit, and region of residence. 2 Adjusted for total cholesterol, SBP, DBP, fasting blood glucose, obesity, smoking, alcohol consumption, and CCI score.