Table 1.

Evidence of a role of sex hormones on the pathophysiology of ocular disorders. ± = no significant evidence, + = weak evidence, ++ = strong evidence.

Ocular Disorder	Evidence of a Role of Sex Hormones on Pathophysiology	Sex Hormones Involved
Dry eye disease (DED)	++	Androgens, Estrogens
Corneal disorders	++	Estrogens
Cataract	+	Estrogens
Glaucoma	+	Estrogens
Leber’s hereditary optic neuropathy (LHON)	++	Estrogens
Demyelinating optic neuritis	++	Estrogens, Progesterone, Androgens
Age-related macular degeneration (AMD)	±	Estrogens
Central serous chorioretinopathy (CSCR)	±	Estrogens
Retinitis pigmentosa	++	Progesterone