TABLE 3.
Values of pharmacokinetic parameters for ribavirin obtained with comodeled data for plasma and urinea
|
t1/2 (h)
|
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subject no. | CLmet (liters/h) | CLR (liters/h) | Vc (liters) | Vss (liters) | V2 (liters) | V3 (liters) | ka (h−1) | k12 (h−1) | k21 (h−1) | k13 (h−1) | k31 (h−1) | F (%) | α | β | γ |
| 1 | 8.894 | 5.359 | 6.080 | 873.4 | 844.5 | 22.86 | 0.383 | 13.22 | 0.095 | 17.64 | 4.691 | 28.2 | 0.019 | 0.332 | 49.64 |
| 2 | 23.29 | 8.323 | 39.46 | 669.3 | 619.4 | 10.40 | 0.312 | 1.981 | 0.126 | 7.095 | 26.93 | 33.1 | 0.020 | 0.308 | 19.87 |
| 3 | 30.38 | 8.797 | 12.80 | 1,113.6 | 1,047.0 | 53.82 | 0.208 | 3.415 | 0.042 | 15.62 | 3.715 | 58.4 | 0.028 | 0.703 | 35.76 |
| 4 | 19.20 | 6.815 | 14.52 | 1,120.1 | 1,077.0 | 28.60 | 0.325 | 5.279 | 0.071 | 14.14 | 7.179 | 84.6 | 0.026 | 0.354 | 39.33 |
| 5 | 20.05 | 8.139 | 11.49 | 607.0 | 566.3 | 29.21 | 0.340 | 4.479 | 0.091 | 7.512 | 2.955 | 66.5 | 0.043 | 0.530 | 22.24 |
| 6 | 6.454 | 4.239 | 22.42 | 711.5 | 667.3 | 21.27 | 0.298 | 2.165 | 0.073 | 2.447 | 2.579 | 40.0 | 0.104 | 0.649 | 55.17 |
| Mean ± SD | 18.06 ± 8.991 | 6.94 ± 1.823 | 17.80 ± 11.86 | 849.20 ± 2253 | 803.67 ± 221.1 | 27.69 ± 14.49 | 0.31 ± 0.058 | 5.09 ± 4.184 | 0.083 ± 0.028 | 10.74 ± 5.924 | 8.01 ± 9.415 | 51.80 ± 21.8 | 0.040 ± 0.032 | 0.480 ± 0.172 | 37.00 ± 14.20 |
a
VSS, volume of distribution at steady state; V2, volume of distribution of the second compartment; V3, volume of distribution of the third compartment. The other abbreviations were defined in the text.