Table 2.

Major paraneoplastic onconeuronal antibodies reactive with neuronal membrane antigens. Adapted from Galli, J.; Greenlee, J. Paraneoplastic Diseases of the Central Nervous System [7].

Antibody	Common Neurological Phenotypes	Common Associated Malignancies
Anti-AMPAR	Limbic encephalitis	Breast Lung Thymus
Anti-LGI1/Anti- CASPR2	Limbic encephalitis Faciobrachial dystonic seizures Morvan’s syndrome	Thymoma (especially in patients positive for both antibodies) Other neoplasms (rare)
Anti-GABAbR	Limbic encephalitis, status epilepticus	Small-cell lung cancer
Anti-mGluR1	Cerebellar degeneration	Hodgkin’s disease
Anti-mGlur2	Cerebellar degeneration	Small-cell cancer; alveolar rhabdomyosarcoma
Anti-mGluR5	Limbic encephalitis	Hodgkin’s disease
Anti-VGKC	Cerebellar degeneration (Lambert–Eaton myasthenic syndrome)	Small-cell lung cancer