Table 1.
Incidence/persistence/clearance of anal HPV infection among men who have sex with men.
| HPV Genotypes | Incident Infections | Person Months | Incidence/1000 Person Months (95% CI) | Persistent Infections | Person Months | Persistence/1000 Person Months (95% CI) | Cleared Infections | Person Months | Clearance/1000 Person Months (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
| Any genotype a | 77 | 2457 | 31.3 (24.7–39.2) | 63 | 1314 | 47.9 (36.8–61.3) | 161 | 1314 | 122.5 (104.3–143.0) |
| HR genotypes | |||||||||
| Any HR genotype | 42 | 2457 | 17.1 (12.3–23.1) | 38 | 922 | 41.2 (29.2–56.6) | 81 | 922 | 87.9 (69.8–109.2) |
| HPV 16 | 9 | 2187 | 4.1 (1.9–7.8) | 8 | 271 | 29.5 (12.7–58.2) | 14 | 271 | 51.7 (28.2–86.7) |
| HPV 18 | 5 | 2353 | 2.1 (0.7–5.0) | 0 | 104 | 0.0 (0.0–35.5) | 8 | 104 | 76.9 (33.2–151.6) |
| HPV 31 | 0 | 2434 | 0.0 (0.0–1.5) | 0 | 23 | 0.0 (0.0–160.4) | 2 | 23 | 87.0 (10.5–314.1) |
| HPV 33 | 3 | 2409 | 1.2 (0.3–3.6) | 2 | 48 | 41.7 (5.0–150.5) | 2 | 48 | 41.7 (5.0–150.5) |
| HPV 35 | 1 | 2409 | 0.4 (0.0–2.3) | 1 | 48 | 20.8 (0.5–116.1) | 3 | 48 | 62.5 (12.9–182.7) |
| HPV 39 | 3 | 2364 | 1.3 (0.3–3.7) | 4 | 93 | 43.0 (11.7–110.1) | 5 | 93 | 53.8 (17.5–125.5) |
| HPV 45 | 1 | 2380 | 0.4 (0.0–2.3) | 1 | 77 | 13.0 (0.3–72.4) | 5 | 77 | 64.9 (21.1–151.5) |
| HPV 51 | 4 | 2296 | 1.7 (0.5–4.5) | 6 | 161 | 37.3 (13.7–81.1) | 6 | 161 | 37.3 (13.7–81.1) |
| HPV 52 | 7 | 2223 | 3.1 (1.3–6.5) | 4 | 234 | 17.1 (4.7–43.8) | 14 | 234 | 59.8 (32.7–100.4) |
| HPV 56 | 1 | 2417 | 0.4 (0.0–2.3) | 0 | 40 | 0.0 (0.0–92.2) | 3 | 40 | 75.0 (15.5–219.2) |
| HPV 58 | 4 | 2271 | 1.8 (0.5–4.5) | 8 | 186 | 43.0 (18.6–84.7) | 8 | 186 | 43.0 (18.6–84.7) |
| HPV 59 | 2 | 2382 | 0.8 (0.1–3.0) | 1 | 76 | 13.2 (0.3–73.3) | 4 | 76 | 52.6 (14.3–134.8) |
| HPV 68 | 2 | 2339 | 0.9 (0.1–3.1) | 3 | 118 | 25.4 (5.2–74.3) | 7 | 118 | 59.3 (23.9–122.2) |
| LR genotypes | |||||||||
| Any LR genotype | 35 | 2457 | 14.2 (9.9–19.8) | 25 | 902 | 27.7 (17.9–40.9) | 80 | 902 | 88.7 (70.3–110.4) |
| HPV 6 | 2 | 2246 | 0.9 (0.1–3.2) | 10 | 211 | 47.4 (22.7–87.2) | 8 | 211 | 37.9 (16.4–74.7) |
| HPV 11 | 4 | 2239 | 1.8 (0.5–4.6) | 4 | 218 | 18.3 (5.0–47.0) | 12 | 218 | 55.0 (28.4–96.2) |
| HPV 26 | 1 | 2447 | 0.4 (0.0–2.3) | 0 | 11 | 0.0 (0.0–335.4) | 1 | 11 | 90.9 (2.3–506.5) |
| HPV 34 | 1 | 2443 | 0.4 (0.0–2.3) | 0 | 14 | 0.0 (0.0–263.5) | 1 | 14 | 71.4 (1.8–398.0) |
| HPV 40 | 3 | 2375 | 1.3 (0.3–3.7) | 2 | 82 | 24.4 (3.0–88.1) | 4 | 82 | 48.8 (13.3–124.9) |
| HPV 42 | 3 | 2339 | 1.3 (0.3–3.7) | 3 | 118 | 25.4 (5.2–74.3) | 9 | 118 | 76.3 (34.9–144.8) |
| HPV 43 | 2 | 2356 | 0.8 (0.1–3.1) | 1 | 101 | 9.9 (0.3–55.2) | 7 | 101 | 69.3 (27.9–142.8) |
| HPV 44 | 0 | 2457 | 0.0 (0.0–1.5) | 0 | 0 | NA | 0 | 0 | NA |
| HPV 53 | 3 | 2405 | 1.2 (0.3–3.6) | 0 | 53 | 0.0 (0.0–69.6) | 4 | 53 | 75.5 (20.6–193.2) |
| HPV 54 | 0 | 2446 | 0.0 (0.0–1.5) | 0 | 11 | 0.0 (0.0–335.4) | 1 | 11 | 90.9 (2.3–506.5) |
| HPV 55 | 1 | 2457 | 0.4 (0.0–2.3) | 0 | 0 | NA | 0 | 0 | NA |
| HPV 57 | 0 | 2457 | 0.0 (0.0–1.5) | 0 | 0 | NA | 0 | 0 | NA |
| HPV 61 | 3 | 2444 | 1.2 (0.3–3.6) | 0 | 13 | 0.0 (0.0–283.8) | 1 | 13 | 76.9 (1.9–428.6) |
| HPV 66 | 2 | 2424 | 0.8 (0.1–3.0) | 0 | 34 | 0.0 (0.0–108.5) | 3 | 34 | 88.2 (18.2–257.9) |
| HPV 67 | 2 | 2435 | 0.8 (0.1–3.0) | 0 | 22 | 0.0 (0.0–167.7) | 2 | 22 | 90.9 (11.0–328.4) |
| HPV 69 | 1 | 2428 | 0.4 (0.0–2.3) | 1 | 29 | 34.5 (0.9–192.1) | 1 | 29 | 34.5 (0.9–192.1) |
| HPV 70 | 0 | 2443 | 0.0 (0.0–1.5) | 0 | 14 | 0.0 (0.0–263.5) | 1 | 14 | 71.4 (1.8–398.0) |
| HPV 71 | 0 | 2443 | 0.0 (0.0–1.5) | 0 | 14 | 0.0 (0.0–263.5) | 1 | 14 | 71.4 (1.8–398.0) |
| HPV 72 | 0 | 2443 | 0.0 (0.0–1.5) | 0 | 15 | 0.0 (0.0–245.9) | 1 | 15 | 66.7 (1.7–371.4) |
| HPV 73 | 0 | 2421 | 0.0 (0.0–1.5) | 1 | 36 | 27.8 (0.7–154.8) | 3 | 36 | 83.3 (17.2–243.5) |
| HPV 81 | 3 | 2429 | 1.2 (0.3–3.6) | 1 | 28 | 35.7 (0.9–199.0) | 2 | 28 | 71.4 (8.7–258.0) |
| HPV 82 | 2 | 2348 | 0.9 (0.1–3.1) | 2 | 110 | 18.2 (2.2–65.7) | 6 | 110 | 54.5 (20.0–118.7) |
| HPV 83 | 0 | 2445 | 0.0 (0.0–1.5) | 0 | 12 | 0.0 (0.0–307.4) | 1 | 12 | 83.3 (2.1–464.3) |
| HPV 84 | 2 | 2318 | 0.9 (0.1–3.1) | 0 | 139 | 0.0 (0.0–26.5) | 11 | 139 | 79.1 (39.5–141.6) |
| Vaccine-preventable genotypes | |||||||||
| 9V genotypes b | 35 | 2457 | 14.2 (9.9–19.8) | 37 | 902 | 41.0 (28.9–56.5) | 73 | 902 | 80.9 (63.4–101.8) |
| 4V genotypes c | 20 | 2457 | 8.1 (5.0–12.6) | 22 | 687 | 32.0 (20.1–48.5) | 42 | 687 | 61.1 (44.1–82.6) |
| 2V genotypes d | 14 | 2408 | 5.8 (3.2–9.8) | 8 | 325 | 24.6 (10.6–48.5) | 22 | 325 | 67.7 (42.4–102.5) |
| HPV 6/11 | 6 | 2457 | 2.4 (0.9–5.3) | 14 | 429 | 32.6 (17.8–54.8) | 20 | 429 | 46.6 (28.5–72.0) |
Abbreviations: HPV, human papillomavirus; CI, confidence interval; HR, high-risk; LR, low-risk; NA, not available; a ≥1 of the 37 genotypes were detected; b 9V genotypes include HPV 6, 11, 16, 18, 31, 33, 45, 52, and 58; c 4V genotypes include HPV 6, 11, 16, and 18; d 2V genotypes include HPV 16 and 18.