Table 1.

Functional alterations of wolframin according to type of WFS1 mutations.

Class		Alterations of Wolframin Function
A absence of wolframin production	A1	Wolframin depletion due to degradation of WFS1 mRNA
	A2	Wolframin depletion due to mRNA and protein degradation
	A3	Wolframin depletion due to degradation of protein
B		Reduced expression of a deficient wolframin
C		Expression of a deficient wolframin