Table 2.
Significantly modulated common gene sets by either BI-D1870, ipatasertib or the combination of BI-D1870 and ipatasertib in NCI-H929 and OPM-2 cells.
| Downregulated by BI-D1870 Plus Ipatasertib |
Upregulated by BI-D1870 Plus Ipatasertib |
Downregulated by BI-D1870 |
Downregulated by Ipatasertib |
Upregulated by Ipatasertib |
|||||
|---|---|---|---|---|---|---|---|---|---|
| Gene Set Name | FDR q-Value |
Gene Set Name | FDR q-Value |
Gene Set Name | FDR q-Value |
Gene Set Name | FDR q-Value |
Gene Set Name | FDR q-Value |
| MYC_UP.V1_UP | 0 | MTOR_UP.N4.V1_DN | 0 | MYC_UP.V1_UP | 0.0072 | MYC_UP.V1_UP | 0 | MTOR_UP.N4.V1_DN | 0.0057 |
| CSR_LATE_UP.V1_UP | 0.0012 | STK33_SKM_UP | 0.0058 | EGFR_UP.V1_UP | 0.0096 | MTOR_UP.N4.V1_UP | 0.0056 | STK33_UP | 0.0205 |
| MTOR_UP.N4.V1_UP | 0.0018 | MYC_UP.V1_DN | 0.0111 | RPS14_DN.V1_ DN |
0.0101 | CSR_LATE_UP.V1_UP | 0.0412 | KRAS.LUNG_UP.V1_DN | 0.0230 |
| RPS14_DN.V1_DN | 0.0020 | STK33_UP | 0.0151 | CSR_EARLY_UP.V1_UP | 0.0103 | − | − | RPS14_DN.V1_ UP |
0.0387 |
| CSR_EARLY_UP.V1_UP | 0.0039 | − | − | RAF_UP.V1_DN | 0.0120 | − | − | − | − |
| VEGF_A_UP.V1_ DN |
0.0045 | − | − | CSR_LATE_UP.V1_UP | 0.0143 | − | − | − | − |
| ESC_V6.5_UP_ LATE.V1_DN |
0.0084 | − | − | ERBB2_UP.V1_ DN |
0.0144 | − | − | − | − |
| IL15_UP.V1_UP | 0.0099 | − | − | VEGF_A_UP.V1_DN | 0.0157 | − | − | − | − |
| ESC_J1_UP_LATE.V1_DN | 0.0179 | − | − | TBK1.DF_DN | 0.0390 | − | − | − | − |
| GCNP_SHH_UP_ LATE.V1_UP |
0.0209 | − | − | MEK_UP.V1_DN | 0.0426 | − | − | − | − |
| EGFR_UP.V1_UP | 0.0234 | − | − | GCNP_SHH_UP_LATE.V1_UP | 0.0449 | − | − | − | − |
| ERBB2_UP.V1_DN | 0.0246 | − | − | STK33_NOMO_UP | 0.0456 | − | − | − | − |
| IL2_UP.V1_UP | 0.0267 | − | − | − | - | − | − | − | − |
| MTOR_UP.V1_UP | 0.0465 | − | − | − | - | − | − | − | − |
| CAMP_UP.V1_UP | 0.0468 | − | − | − | - | − | − | − | − |
Gene set titles are described according to www.gsea-misgdb.org/gsea/index.jsp, accessed on 1 December 2021. FDR: false discovery rate.