TABLE 1.
Residual C. albicans NIH-8621 burden in tissues of untreated control rabbits and rabbits treated with either D-AmB, Flu, L-Nys2, or L-Nys4
| Treatment group | Log CFU/ga
|
||||
|---|---|---|---|---|---|
| Kidney | Liver | Spleen | Lung | Brain | |
| Controls | 6.69 ± 0.28 (8) | 6.30 ± 0.17 (8) | 6.87 ± 0.38 (8) | 4.39 ± 0.34 (8) | 2.89 ± 0.81 (6) |
| D-AmB | 0.28 ± 0.28 (1) | 0 ± 0 (0) | 0 ± 0 (0) | 0 ± 0 (0) | 0 ± 0 (0) |
| Flu | 0.19 ± 0.19 (1) | 0 ± 0 (0) | 0 ± 0 (0) | 0 ± 0 (0) | 0 ± 0 (0) |
| L-Nys2 | 1.05 ± 0.71 (2) | 1.35 ± 0.89 (2) | 0.89 ± 0.67 (2) | 0.97 ± 0.64 (2) | 0.74 ± 0.55 (2) |
| L-Nys4 | 0 ± 0 (0) | 0 ± 0 (0) | 0 ± 0 (0) | 0 ± 0 (0) | 0 ± 0 (0) |
a
All values represent the means ± SEMs for eight rabbits. The number of infected animals is given in parentheses. P was <0.0001 by ANOVA among the five experimental groups.