TABLE 2.
Effects of L-Nys on parameters of renal function as determined by analysis of serum in comparison to effects of no treatment or treatmenta with either AmB-D or Flu
| Treatment group | Creatinine concn (mg/dl) | BUN concn (mg/dl) | Potassium concn (mmol/liter) | Magnesium concn (mmol/liter) | Bicarbonate concn (mmol/liter) |
|---|---|---|---|---|---|
| Controls | 1.76 ± 0.17b (1.10–2.40) | 23.5 ± 2.2b (12.0–34.0) | 3.15 ± 0.15c (2.20–3.60) | 0.76 ± 0.03c (0.59–0.90) | 20.7 ± 0.9 (18.1–25.9) |
| D-AmB | 4.91 ± 0.69 (1.80–7.00) | 133.6 ± 17.7 (62.0–215) | 4.01 ± 0.24 (3.20–5.30) | 0.95 ± 0.02 (0.85–1.05) | 17.1 ± 1.4 (11.7–23.1) |
| Flu | 1.16 ± 0.05b (1.00–1.40) | 21.1 ± 4.8b (7.0–53.0) | 4.34 ± 0.5d (3.70–5.10) | 0.79 ± 0.02 (0.72–0.91) | 23.2 ± 0.7c (20.3–26.3) |
| L-Nys2 | 1.45 ± 0.16b (1.00–2.40) | 22.2 ± 2.6b (12.0–38.0) | 3.93 ± 0.27 (2.50–4.90) | 0.84 ± 0.05 (0.65–1.06) | 21.2 ± 1.1 (17.9–28.0) |
| L-Nys4 | 2.76 ± 0.48e (1.20–5.00) | 48.0 ± 10.2b (19.0–101) | 3.94 ± 0.11 (3.50–4.50) | 0.96 ± 0.05f (0.75–1.15) | 19.2 ± 1.6 (11.7–25.3) |
| Normal values | 0.72 ± 0.02 (0.50–1.00) | 18.0 ± 0.71 (13.0–26.0) | 4.50 ± 0.08 (3.80–5.40) | 91 ± 0.01 (0.82–1.05) | 26 ± 0.29 (22.0–29.0) |
a
All values for experimental rabbits represent the means ± SEMs for eight rabbits; normal values (means ± SEMs) are derived from 24 healthy, catheterized rabbits. Values in parentheses are ranges. All P values were determined by ANOVA and Bonferroni’s correction for multiple comparisons.
b
P < 0.001 versus D-AmB-treated animals.
c
P < 0.05 versus D-AmB-treated animals.
d
P < 0.01 versus untreated control animals.
e
P < 0.01 versus D-AmB-treated animals.
f
P < 0.05 versus controls and Flu-treated animals.