Table 5.

Selectivity index (MIC₉₀/IC₅₀) of nitrofuran derivatives against different fungi species compared to the MRC-5 lung cells.

		Calculated SI
Compounds	MRC5 IC50 (µg/mL)	C. albicans	C. krusei	C. glabrata	C. neoformans	H. capsulatum	P. brasiliensis	T. rubrum	T. mentagrophytes
1	240.5	61.66	7.69	30.79	7.69	0.96	61.66	0.96	15.41
2	90.75	0.36	0.36	0.36	0.36	0.36	2.90	0.72	0.72
3	250.00	1.00	1.00	1.00	8.00	64.10	520.83	2.00	4.00
4	135.2	0.54	0.54	0.54	8.66	34.66	34.66	1.08	4.32
5	39.76	0.31	0.63	0.31	10.19	20.38	2.54	2.54	1.27
6	15.6	0.06	0.06	0.06	0.06	0.06	0.49	0.06	0.06
7	71.24	0.28	0.28	0.28	1.13	72.69	36.53	0.56	0.56
8	6.66	0.85	0.02	0.85	0.21	0.42	6.86	6.79	6.79
9	47.23	3.02	0.18	1.51	3.02	12.11	98.39	48.19	24.22
10	215.4	0.86	0.86	0.86	0.86	27.58	222.06	55.23	55.23
11	62.56	0.50	0.25	0.25	0.25	130.33	64.49	8.02	8.02
12	228	0.91	0.91	0.91	0.91	29.19	58.46	232.65	116.92
13	4.15	0.01	0.01	0.01	0.01	0.03	4.23	4.23	4.23
14	26.8	1.71	1.71	3.43	6.87	3.43	13.74	13.74	13.74
15	11.51	0.04	0.04	0.04	0.04	0.04	2.95	1.47	1.47
16	29.89	0.11	0.11	0.11	0.11	0.47	15.09	3.83	3.83
17	1.56	0.006	0.006	0.006	0.006	0.006	0.80	0.006	0.006