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. 2022 Mar 4;12(3):396. doi: 10.3390/jpm12030396

Figure 2.

Figure 2

The protein–protein network. The protein–protein interaction (PPI) between MMR proteins comprising MLH1, MSH2, MSH6, PMS2, and 22 FA proteins was exported from the STRING database (high confidence (0.7)) [80] and visualized by using Cytoscape software, version 3.8.2 [81]. The association network shows that FANCS, FANCD1, FANCO, and FANCQ are linked with all selected MMR proteins, while FANCM interacts with MSH6, MSH2, and MLH1. FANCD2 is connected to MSH2 and MLH1, whereas FANCJ is associated with MLH1 and PMS2. The FA proteins without direct association with selected MMR proteins have been excluded.