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The FA pathway involvement in CRC treatment. The DNA damages caused by radio- and chemotherapy in CRC cells result in cell death. On the other side, up-regulation of the FA pathway components such as RAD51, BRCA1/2, XRCC2, and REV7 leads to HR restoration and drug resistance. The deficiency in the FA pathway components such as BRCA1/2, XRCC2, and RAD51 represents the synthetic lethal relationship with PARP1, which might introduce druggable candidates for PARP inhibitors in CRC cells.
