APC	APC regulator of WNT signaling pathway
ATR	ataxia telangiectasia and RAd3-related kinase
BCDX2 complex	RAD51 paralogs (RAD51B, RAD51C, RAD51D) and XRCC2
BMPR1A	bone morphogenetic protein receptor type 1A
BRAF	B-Raf proto-oncogene, serine/threonine kinase
BRCA	BRCA1 DNA repair associated (alias FANCS)
BRCA2	BRCA2 DNA repair associated (alias FANCD, FANCD1)
BRIP1	BRCA1 interacting helicase 1 (alias FANCJ)
CHK1	checkpoint kinase1
CNV	copy number variation
CRC	colorectal cancer
dNTP	deoxyribonucleoside triphosphate
DSB	double-strand break
EOCRC	early-onset CRC
ERCC1	ERCC excision repair 1, endonuclease catalytic subunit
ERCC4	ERCC excision repair 4, endonuclease catalytic subunit (alias FANCQ)
FA	Fanconi anemia
FAAP	RNA 2′,3′-cyclic phosphate and 5′-OH ligase
FAAP100	FA core complex associated protein 100
FAAP20	FA core complex associated protein 20
FAAP24	FA core complex associated protein 24
FAN1	FANCD2 and FANCI associated nuclease 1
FANC	FA complementation group
FANCA	FA complementation group A
FANCB	FA complementation group B
FANCC	FA complementation group C
FANCD1	BRCA2 DNA repair associated (official symbol BRCA2)
FANCD2	FA complementation group D2
FANCE	FA complementation group E
FANCF	FA complementation group F
FANCG	FA complementation group G (alias XRCC9)
FANCI	FA complementation group I
FANCJ	BRCA1 interacting helicase 1 (official symbol BRIP1)
FANCL	FA complementation group L
FANCM	FA complementation group M
FANCN	partner and localizer of BRCA2 (official symbol PALB2)
FANCO	RAD51 paralog C (official symbol RAD51C)
FANCP	SLX4 structure-specific endonuclease subunit
FANCQ	ERCC excision repair 4, endonuclease catalytic subunit (official symbol ERCC4)
FANCR	RAD51 recombinase (official symbol RAD51)
FANCS	BRCA1 DNA repair associated (official symbol BRCA)
FANCT	FA complementation group T/Ubiquitin Conjugating Enzyme E2 T (official symbol UBE2T)
FANCU	X-ray repair cross complementing 2 (official symbol XRCC2)
FANCV	mitotic arrest deficient 2 like 2 (official symbol: MAD2L2; alias REV7)
FANCW	ring finger and WD repeat domain 3 (official symbol RFWD3)
FCCTX	familial CRC type X
FOLFIRI	fluorouracil/leucovorin, irinotecan
FOLFOX	fluorouracil/leucovorin, oxaliplatin
G4	G-quadruplex
GEO	Gene Expression Omnibus
HR	homologous recombination
HRR	homologous recombinational repair
ICL	inter-strand crosslink
ID2 complex	FANCI-FANCD2
KRAS	Kirsten RAS proto-oncogene
LARC	locally advanced rectal cancer
mCRC	metastatic CRC
MEK1	mitogen-activated protein kinase kinase 1 (official symbol MAP2K1)
MEK2	mitogen-activated protein kinase kinase 2 (official symbol MAP2K2)
MHF1	centromere protein S (official symbol CENPS)
MHF2	centromere protein X (official symbol CENPX)
MLH1	mutL homolog 1
MLH2	PMS1 homolog 1, mismatch repair system component (official symbol PMS1)
MMR	mismatch repair,
MRN complex	MRE11-RAD50-NBS proteins
MSH2	mutS homolog 2
MSH6	mutS homolog 6
MSI	microsatellite instability
MSS	microsatellite stability
MUTYH	mutY DNA glycosylase
NCI GDC	National Cancer Institute-Genomic Data Commons
NER	nucleotide excision repair
NGS	next-generation sequencing;
NHEJ	non-homologous end joining
NTHL	nth like DNA glycosylase
PALB2	partner and localizer of BRCA2 (alias FANCN)
PARP1	poly (ADP-ribose) polymerase 1
PARPi	PARP inhibitor
PFS	progression-free survival
PMS2	PMS1 homolog 2, mismatch repair system component
POLD1	DNA polymerase delta 1, catalytic subunit
POLE	DNA polymerase epsilon, catalytic subunit
POLQ	DNA polymerase theta
PPAP	polymerase proofreading–associated polyposis
PPI	protein–protein interaction
PTEN	phosphatase and tensin homolog
PV	pathogenic variation
RAD51	RAD51 recombinase (alias FANCR)
RAD51B	RAD51 paralog B
RAD51C	RAD51 paralog C (alias FANCO)
RAD51D	RAD51 paralog D
REV1	REV1 DNA directed polymerase
REV7	mitotic arrest deficient 2 like 2 (official symbol: MAD2L2; alias FANCV)
RFWD3	ring finger and WD repeat domain 3 (alias FANCW)
RNaseH	ribonuclease H
SMAD4	SMAD family member 4
ssDNA	single-strand DNA
STK11	serine/threonine kinase 11
TLS	translesion DNA synthesis
TMEJ	polymerase theta-mediated end joining
TMS	telomestatin
TNM	tumor (lymph) node metastasis staging
TP53	tumor protein p53
UBE2T	Ubiquitin Conjugating Enzyme E2 T (alias FANCT)
VEGF	Vascular endothelial growth factor
WES	whole-exome sequencing
XRCC2	X-ray repair cross complementing 2 (alias FANCU)