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. 2022 Mar 10;13(3):428. doi: 10.3390/mi13030428

Figure 3.

Figure 3

Modeling Alcoholic Liver Disease using microfluidic devices. (A) ALD Liver-Chip model with approach of exposing to alcohol [67] (reproduced with permission from Nawroth et al., 2020 Copyright: Cell Reports 36, 109393, July 20, 2021). (B) ALD model prepared by culturing primary hepatocytes with stellate cells in PDMS based Liver-on-Chip [68] (reproduced with permission from Lee et al., 2016). (C) Liver injury-on-a-chip representing non-mixing channels for co-culture growth [69], adapted from Zhou et al., 2015. (D) Liver-chip-based ALD design based on PMMA device with PDMS spaces and PC membrane to maintain cell lines [70] (reproduced with permissions from Deng et al., 2019).