TABLE 3.
Pulmonary lesions and pneumococcal concentrations in rabbits with penicillin-resistant S. pneumoniae (strain 16089) experimental pneumonia, according to death circumstances
| Parameter | Result or concentration for death at the following time by the indicated causea
|
|||
|---|---|---|---|---|
| 24 h
|
48 h
|
|||
| Pneumonia-related death | Sacrificed (P) | Pneumonia-related death | Sacrificed (P) | |
| No. | 5 | 5 | 5 | 5 |
| Macroscopic score | 22.60 ± 7.27 | 22.40 ± 5.18 (1.00) | 24.00 ± 6.20 | 11.60 ± 6.54 (0.04) |
| Histopathological score | 12.50 ± 2.12 | 17.00 ± 1.51 (0.88) | 21.67 ± 3.21 | 9.00 ± 4.16 (0.03) |
| Pneumococcal concentration in lungsb | 6.87 ± 0.25 | 3.93 ± 2.35 (0.009) | 4.10 ± 1.88 | 3.61 ± 1.51 (0.92) |
| Pneumococcal concentration in spleenb | 5.26 ± 1.71 | 3.83 ± 2.79 (0.35) | 2.98 ± 2.15 | 3.34 ± 2.19 (0.92) |
a
Each value represents the mean ± SD or number and percentage. P values were determined by the Mann-Whitney test.
b
Log10 CFU/g.