TABLE 4.

Effects of treatment by amoxicillin (oral and intravenous simulation) on penicillin-resistant (strain 16089) and penicillin-susceptible (strain 195) S. pneumoniae experimental pneumonia

Parameter	Result or concentration for the following straina
	Penicillin-resistant S. pneumoniae (strain 16089)				Penicillin-susceptible S. pneumoniae (strain 195)
	Untreated	Treated		Pd	Untreated	Treated		Pd
		Oralb	Intravenousc			Oralb	Intravenousc
No.	8	5	5		8	5	5
Death at 48 h (%)	4/8 (50)	0/5 (0)	0/5 (0)	0.02	4/8 (50)	0/5 (0)	0/5 (0)	0.02
Macroscopic score	17.5 ± 10.4	12.0 ± 6.8	11.8 ± 1.3	0.36	17.8 ± 7.5	22.6 ± 5.9	16.4 ± 5.4	0.31
Histopathologic score	14.0 ± 8.3	16.6 ± 8.3	15.2 ± 5.0	0.78	13.1 ± 5.4	17.6 ± 2.6	15.6 ± 4.3	0.24
Sterilized lungs (%)	0/8 (0)	3/5 (60)	3/5 (60)	0.01	0/8 (0)	4/5 (80)	5/5 (100)	<0.001
Pneumococcal concentration in lungse	5.07 ± 2.05	1.63 ± 1.02	1.44 ± 0.81	<0.001	6.49 ± 1.33	1.05 ± 0.11	1.00 ± 0.00	<10−6
Pneumococcal concentration in spleene	4.40 ± 2.37	1.00 ± 0.00	1.00 ± 0.00	<10−6	5.00 ± 2.10	1.00 ± 0.00	1.00 ± 0.00	<10−6

^aEach value represents the mean ± SD or number and percentage. 

^bSimulation of four amoxicillin (1-g) oral administrations every 8 h. 

^cSimulation of five amoxicillin (1-g) intravenous administrations every 8 h. 

^dOne-way variance analysis. 

^eLog₁₀ CFU/g.