Table 1.
23 full factorial design variables and constraints.
| Independent Variables | Levels | ||
|---|---|---|---|
| −1 | +1 | Constrains | |
| A: Surfactant concentration (mg) | 100 | 200 | In range |
| B: CH:LP molar ratio (w/w) | 2:1 | 4:1 | In range |
| C: SDC concentration (mg) | 10 | 25 | In range |
| Dependent variables | |||
| R1: VS (nm) | Minimize | ||
| R2: EE (%) | Maximize | ||
| R3: ZP (mV) | Maximize | ||
| R4: Q8 h (%) | Maximize | ||
LP: Lipoid®S100 ratio, CH: cholesterol, SDC: sodium deoxycholate, VS: vesicle size, %EE: % entrapment efficiency, ZP: zeta potential, and %Q8 h: % drug dissolved after 8 h.