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. 2022 Mar 18;23(6):3284. doi: 10.3390/ijms23063284

Figure 1.

Figure 1

TNFR1 (a) and TNFR2 (b) mediated signaling pathways. Akt, protein kinase B; AP-1, activator protein-1; ASK-1, apoptosis signal-regulating kinase-1; c-FLIPʟ, cellular FLICE-inhibitory protein; cIAP1/2, cellular inhibitor of apoptosis protein 1 or 2; Etk, endothelial/epithelial protein tyrosine kinase; FADD, Fas-associated death domain; IKK, inhibitor of kappa B kinase; IκB, NF-ĸB inhibitor; JNK, c-jun kinase; LUBAC, linear ubiquitin chain assembly complex; MAPK, mitogen activated protein kinase; MLKL, mixed lineage kinase domain-like protein; NEMO, NF-κB essential modulator; NF-ĸB, nuclear factor kappa B; NIK, NF-κB inducing kinase; PI3K, phosphatidylinositol 3-kinase; RIPK1/3, receptor interacting serine/threonine-protein kinase 1 or 3; SODD, silencer of death domains; TAB, TAK-binding proteins; TAK1, transforming growth factor-beta-activated kinase 1; TNFR1, tumor necrosis factor receptor 1; TNFR2, tumor necrosis factor receptor 2; TNF-α, tumor necrosis factor alpha; TRADD, TNF receptor-associated death domain; TRAF1/2, TNF receptor-associated factor 1 or 2.