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. 1999 Oct;43(10):2497–2503. doi: 10.1128/aac.43.10.2497

TABLE 1.

Structure and IMP-1 metallo-β-lactamase-inhibitory activity of J-110,441 analogs  

graphic file with name ac1090194t1a.jpg

Compound R1 R2 IC50 (μM)a
J-110,441 graphic file with name ac1090194t1b.jpg H <0.1
1a H 0.70
1b Me >10
1c H >10
2a H 2.4
2b H >10
 
a

Nitrocefin was used as a substrate.