TABLE 2.
Structure and IMP-1 metallo-β-lactamase-inhibitory activity of dithiocarbamate carbapenem analogs
| Compound | R | IC50 (μM)a |
|---|---|---|
| 3a |  |
<0.1 |
| 3b | <0.1 | |
| 3c | 0.22 | |
| 3d | 0.22 | |
| 3e |  |
0.50 |
| 3f | 1.4 | |
| 3g | 1.8 | |
a
Nitrocefin was used as a substrate.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.