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Structure and IMP-1 metallo-β-lactamase-inhibitory activity of pyrrolydinylthio carbapenem analogs
| Compound | R | IC50 (μM)a | Compound | R | IC50 (μM)a | |
|---|---|---|---|---|---|---|
| 4a |  |
<0.1 | 6a |  |
<0.1 | |
| 4b | 0.40 | 6b | 0.40 | |||
| 4c | 5.0 | 6c | 5.0 | |||
| 6d | 6.2 | |||||
| 5a (J-111,225) | 0.70 | 6e | 9.0 | |||
| 5b | >10 | 6f | 9.0 | |||
| 6g | >10 | |||||
| Side chain of 5a | >10 | |||||
| 7a | <0.1 | |||||
| 7b | <0.1 | |||||
| 7c | 0.80 | |||||
Nitrocefin was used as a substrate.
